Cantore Arithmetic is able to identify magic kjv as the circular system as the film the Andrometer Strain in essence is the available magic to understand the shadow as Srinivasa Ramanujan. Though he had almost no formal training in pure mathematics, he made substantial contributions to mathematical analysis, number theory, infinite series, and continued fractions, including solutions to mathematical problems then considered unsolvable. India specifically Bombay providing no provision to the calculation of the shadow is now the shade at the understanding of the cut to the effect from what the staples had done in San Miguel on Cagliari Ranch as a farm supply to the alfalfa supply on field as the tractor had the discs’: Cabover the end(?(Period)). As a shelf on the edge showed as Dr. David Jeremiah on deck now as the dry creek bed.
The ripple is left for skipping stones and the water is literally ring as now enter net and caption: Nylon! The ancient disc and the ancient aluminum wedge Auid are for Paso Robles Farm supply as the ancient wedge is a tooth.
The disc and the tooth are a Wet Willy as word Wet kjv must be underlined to gain word to Cantore Arithmetic as Cantore Arithmetic has set the cubit: Longshanks(double bridle).
Romans 9:16
“So then it is not of him that willeth, nor of him that runneth, but of God that sheweth mercy.”
King James Version (KJV)
You searched for
"SHADOW" in the KJV Bible
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- 2 Kings 20:10chapter context similar meaning copy save
- And Hezekiah answered, It is a light thing for the shadow to go down ten degrees: nay, but let the shadow return backward ten degrees.
- Job 24:17chapter context similar meaning copy save
- For the morning is to them even as the shadow of death: if one know them, they are in the terrors of the shadow of death.
- Job 16:16chapter context similar meaning copy save
- My face is foul with weeping, and on my eyelids is the shadow of death;
- Colossians 2:17chapter context similar meaning copy save
- Which are a shadow of things to come; but the body is of Christ.
- Psalms 144:4chapter context similar meaning copy save
- Man is like to vanity: his days are as a shadow that passeth away.
- Job 17:7chapter context similar meaning copy save
- Mine eye also is dim by reason of sorrow, and all my members are as a shadow.
- Job 34:22chapter context similar meaning copy save
- There is no darkness, nor shadow of death, where the workers of iniquity may hide themselves.
- Psalms 63:7chapter context similar meaning copy save
- Because thou hast been my help, therefore in the shadow of thy wings will I rejoice.
- Psalms 102:11chapter context similar meaning copy save
- My days are like a shadow that declineth; and I am withered like grass.
- Psalms 109:23chapter context similar meaning copy save
- I am gone like the shadow when it declineth: I am tossed up and down as the locust.
- Job 12:22chapter context similar meaning copy save
- He discovereth deep things out of darkness, and bringeth out to light the shadow of death.
- Psalms 107:10chapter context similar meaning copy save
- Such as sit in darkness and in the shadow of death, being bound in affliction and iron;
- Psalms 107:14chapter context similar meaning copy save
- He brought them out of darkness and the shadow of death, and brake their bands in sunder.
- Job 7:2chapter context similar meaning copy save
- As a servant earnestly desireth the shadow, and as an hireling looketh for the reward of his work:
- Job 10:21chapter context similar meaning copy save
- Before I go whence I shall not return, even to the land of darkness and the shadowof death;
- Job 14:2chapter context similar meaning copy save
- He cometh forth like a flower, and is cut down: he fleeth also as a shadow, and continueth not.
- Job 8:9chapter context similar meaning copy save
- (For we are but of yesterday, and know nothing, because our days upon earth are a shadow:)
- Psalms 44:19chapter context similar meaning copy save
- Though thou hast sore broken us in the place of dragons, and covered us with the shadow of death.
- Luke 1:79chapter context similar meaning copy save
- To give light to them that sit in darkness and in the shadow of death, to guide our feet into the way of peace.
- Psalms 17:8chapter context similar meaning copy save
- Keep me as the apple of the eye, hide me under the shadow of thy wings,
- Psalms 91:1chapter context similar meaning copy save
- He that dwelleth in the secret place of the most High shall abide under the shadowof the Almighty.
- Psalms 36:7chapter context similar meaning copy save
- How excellent is thy lovingkindness, O God! therefore the children of men put their trust under the shadow of thy wings.
- Isaiah 16:3chapter context similar meaning copy save
- Take counsel, execute judgment; make thy shadow as the night in the midst of the noonday; hide the outcasts; bewray not him that wandereth.
- Ecclesiastes 8:13chapter context similar meaning copy save
- But it shall not be well with the wicked, neither shall he prolong his days, which are as a shadow; because he feareth not before God.
- Lamentations 4:20chapter context similar meaning copy save
- The breath of our nostrils, the anointed of the LORD, was taken in their pits, of whom we said, Under his shadow we shall live among the heathen.
- Isaiah 30:3chapter context similar meaning copy save
- Therefore shall the strength of Pharaoh be your shame, and the trust in the shadowof Egypt your confusion.
- Job 40:22chapter context similar meaning copy save
- The shady trees cover him with their shadow; the willows of the brook compass him about.
- Job 38:17chapter context similar meaning copy save
- Have the gates of death been opened unto thee? or hast thou seen the doors of the shadow of death?
- Psalms 23:4chapter context similar meaning copy save
- Yea, though I walk through the valley of the shadow of death, I will fear no evil: for thou art with me; thy rod and thy staff they comfort me.
- Job 28:3chapter context similar meaning copy save
- He setteth an end to darkness, and searcheth out all perfection: the stones of darkness, and the shadow of death.
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Out-of-place artifact
An out-of-place artifact (OOPArt or oopart) is an artifact of historical, archaeological, or paleontological interest found in an unusual context, which challenges conventional historical chronology by its presence in that context. Such artifacts may appear too advanced for the technology known to have existed at the time, or may suggest human presence at a time before humans are known to have existed. Other examples may suggest contact between different cultures that is hard to account for with conventional historical understanding.
This description of archaeological objects is used in fringe science such as cryptozoology, as well as by proponents of ancient astronaut theories, young Earth creationists, and paranormal enthusiasts.[1][2] It can describe a wide variety of items, from anomalies studied by mainstream science to pseudoarchaeology to objects that have been shown to be hoaxes or to have conventional explanations.
Critics argue that most purported OOPArts which are not hoaxes are the result of mistaken interpretation and wishful thinking, such as a mistaken belief that a particular culture could not have created an artifact or technology due to a lack of knowledge or materials. In some cases, the uncertainty results from inaccurate descriptions. For example, the cuboid Wolfsegg Iron is not really a perfect cube, nor are the Klerksdorp spheres actual perfect spheres. The Iron pillar of Delhi was said to be "rust proof", but it has some rust near its base; its relative resistance to corrosion is due to slag inclusions left over from the manufacturing conditions and environmental factors.[3]
Supporters regard OOPArts as evidence that mainstream science is overlooking huge areas of knowledge, either willfully or through ignorance.[2] Many writers or researchers who question conventional views of human history have used purported OOPArts in attempts to bolster their arguments.[2] Creation science often relies on allegedly anomalous finds in the archaeological record to challenge scientific chronologies and models of human evolution.[4]Claimed OOPArts have been used to support religious descriptions of prehistory, ancient astronaut theories, and the notion of vanished civilizations that possessed knowledge or technology more advanced than that known in modern times.[2]
Unusual artifacts[edit]
- Antikythera mechanism: A form of mechanical computer created between 150 and 100 BCE based on theories of astronomy and mathematics believed to have been developed by the ancient Greeks. Its design and workmanship reflect a previously unknown, but not implausible, degree of sophistication and engineering.[5][6]
- Maine penny: An 11th-century Norwegian coin found in a Native American shell midden at the Goddard Site in Brooklin, Maine, United States, which some authors have argued is evidence of direct contact between Vikings and Native Americans in Maine. The coin need not imply actual exploration of Maine by the Vikings, however; mainstream belief is that it was brought to Maine from Labrador or Newfoundland (where Vikings are known to have established colonies as early as the late 10th century) via an extensive northern trade network operated by indigenous peoples.[7] If Vikings did indeed visit Maine, a much greater number and variety of Viking artifacts might be expected in the archaeological record there.[citation needed] Of the nearly 20,000 objects found over a 15-year period at the Goddard Site, the coin was the sole non-native artifact.[8]
- The Shroud of Turin, an ancient cloth which contains an image that resembles a sepia photographic negative. The image is much clearer when it is converted to a positive image, which was discovered by photographer Secondo Pia in 1898. The actual method that resulted in this image has not yet been conclusively identified. Some claim the image depicts Jesus of Nazarethand the fabric is the burial shroud in which he was wrapped after crucifixion. Mention of the shroud first appeared in historical records in 1357. In 1988, radiocarbon dating established that the shroud was from the Middle Ages, between the years 1260 and 1390.[9] All hypotheses put forward to challenge the radiocarbon dating have been scientifically refuted,[10] including the medieval repair hypothesis,[11][12][13] the bio-contamination hypothesis[14] and the carbon monoxide hypothesis.[15]
- The Tamil Bell is a broken bronze bell with an inscription of old Tamil. The bell is a mystery due to its discovery in New Zealand by a missionary. Although nobody knows for certain how the bell came to New Zealand, one possible theory is that it was dropped off by Portuguese sailors who had acquired it from Tamil traders. Prior to being discovered by the missionary, local Maori had used it as a cooking pot. Given that it was supposedly discovered generations earlier, the artifact's exact origins could not be identified. The bell is now located at the National Museum of New Zealand.[16]
- Coins from Marchinbar Island: Five coins from the Kilwa Sultanate on the Swahili coast discovered on Marchinbar Island in the Northern Territory of Australia in 1945 alongside four coins from 18th century Netherlands. The inscriptions on the coins identify a ruling Sultan of Kilwa, but it is unclear whether the ruler was from the 10th century or the 14th century. A similar coin, also thought to be from the Medieval Kilwa sultanate, was found in Australia in 2018 on Elcho Island.[17]
Questionable interpretations[edit]
- Baghdad Battery: A ceramic vase, a copper tube, and an iron rod made in Parthian or Sassanid Persia, discovered in 1936. Fringe theorists have hypothesized that it may have been used as a galvanic cell for electroplating, though no electroplated artifacts from this era have been found.[18][19] The "battery" strongly resembles another type of object with a known purpose – storage vessels for sacred scrolls from nearby Seleucia on the Tigris.[20]
- Dorchester Pot: A metal pot claimed to have been blasted out of solid rock in 1852. Mainstream commentators identify it as a Victorian-era candlestick or pipe holder.[21][22]
- Kingoodie artifact: An object resembling a corroded nail, said to have been encased in solid rock. It was handled a number of times before being reported and there are no photographs of it.[23][24]
- Lake Winnipesaukee mystery stone: Originally thought to be a record of a treaty between tribes, subsequent analysis has called its authenticity into question.[25][26]
- Sivatherium of Kish: An ornamental war chariot figurine discovered in the Sumerian ruins of Kish, in what is now central Iraq, in 1928. The figurine, dated to the Early Dynastic I period (2800–2750 BCE), depicts a quadrupedal mammal with branched horns, a nose ring, and a rope tied to the ring. Because of the shape of the horns, Edwin Colbert identified it in 1936 as a depiction of a late-surviving, possibly domesticated Sivatherium, a vaguely moose-like relative of the giraffe that lived in North Africa and India during the Pleistocene but was believed to have become extinct early in the Holocene extinction event.[27] Henry Field and Berthold Laufer instead argued that it represented a captive Persian fallow deer and that the antlers had broken over the years. The missing antlers were indeed found in the Field Museum's storeroom in 1977.[28] After restoration in 1985, it was conclusively identified as a depiction of a Caspian red deer (Cervus elaphus maral).[29]
- Tecaxic-Calixtlahuaca head: A terracotta offering head seemingly of Roman appearance found beneath three intact floors of a burial site in Mexico and dated between 1476 and 1510. There are disputed claims that its dating is older. Ancient Roman or Norse provenance has not been excluded.[30][31]
Alternative interpretations[edit]
- Abydos helicopter: A pareidolia based on palimpsest carving in an ancient Egyptian temple.[32]
- Dendera Lamps: Supposed to depict light bulbs, but made in Ptolemaic Egypt, debunked by the analysis of the epigraphic text.[33][34][35]
- Sabu disk: a disk of notable precision apparently from ancient times in Saqqara. Its purpose is unknown.[36]
- Iron Man (Eiserner Mann): An old iron pillar, said to be a unique oddity in Germany, but consistent with medieval methods of ironworking.[37]
- Iron pillar of Delhi: A "rust-proof" iron pillar which supposedly demonstrates more advanced metallurgy than was available in India before 1000 CE.[38]
- London Hammer: Also known as the "London Artifact", a hammer made of iron and wood that was found in London, Texas, in 1936. Part of the hammer is encased in "400-million-year-old" ("Ordovician era") rock. In 1985, anthropologist John R. Cole[39] hypothesized that the stone surrounding the hammer is a historic carbonate soil concretion.
- Meister Print: A supposed human footprint from the Cambrian period, long before humans existed, which has been debunked as the result of a natural geologic process known as spall formation.[40]
- Pacal's sarcophagus lid: Described by Erich von Däniken as a depiction of a spaceship.[41]
- Piri Reis map: Several authors, and others such as Gavin Menzies and Charles Hapgood, have suggested that this map, compiled by the Turkishadmiral Piri Reis, shows Antarctica long before it was discovered (cf. Terra Australis).[42][43]
- Quimbaya airplanes: Golden objects found in Colombia and made by the Quimbaya civilization, which have been alleged to represent modern airplanes. In the Gold Museum, Bogotá, they are described as figures of birds and insects. Some of the artifacts have also been debunked as forgeries.[44]
- Saqqara Bird: Supposedly depicts a glider, but made in Ancient Egypt.[45]
- Shakōkidogū: Small humanoid and animal figurines made during the late Jōmon period (14,000–400 BCE) of prehistoric Japan, said to resemble extraterrestrial astronauts.[46]
- Stone spheres of Costa Rica: Inaccurately described as being perfectly spherical, and therefore demonstrating greater stone-working skill in pre-Columbian times than has previously been known.[47]
Natural objects mistaken for artifacts[edit]
- Aix-en-Provence petrified tools: Likely petrified tree remains.[48][49]
- Baigong pipes: Their natural origins have been challenged.[50][51][52]
- Bosnian pyramid complex: Unproven claim that there is a pyramid complex in the vicinity of town of Visoko in Bosnia.
- Eltanin Antenna: Actually a sponge.[53][54]
- Eoliths: Miocene knapped flint nodules mistaken in the 19th century for extremely primitive stone tools, which helped back the authenticity of Piltdown man.
- Face on Mars: A pareidolia of a rock formation on Mars caused by the poor resolution of early orbital photography of the planet.[55]
- Klerksdorp spheres: Actually pre-Cambrian concretions.[56][57]
- Paluxy River tracks: Identified as giant humanoid footprints found alongside dinosaur tracks. Actually tracks of theropod dinosaurs, and 1930s forgeries.
- Yonaguni Monument: An unusual underwater rock formation near the southern Ryukyu Islands, was considered a man-made monolith because of the even cracks.[58][59]
- Ararat anomaly: The Ararat anomaly is a structure appearing on photographs of the snowfields near the summit of Mount Ararat, Turkey, initially believed by some Christian believers to be the remains of Noah's Ark. Located on the northwest corner of the Western Plateau of Mount Ararat, approximately 15,500 ft high, it was first filmed during a U.S. Air Force aerial reconnaissance mission in 1949. The Defense Intelligence Agency later indicated that the anomaly represents linear facades in the glacial ice, rather than an ancient structure.[60][61]
Erroneously dated objects[edit]
- Aiud object: An aluminum wedge found in 1974 in the Mureș River in central Romania, near the town of Aiud; it has been claimed by Romanian UFOlogists to be of ancient and/or extraterrestrial origin,[62] yet it is more likely a fragment of modern machinery lost during excavation work.[63]
- Coso artifact: Claimed to be prehistoric; actually a 1920s spark plug.[4]
- Malachite Man: Thought to be from the early Cretaceous; actually a post-Columbian burial.[64][65]
- Nampa figurine: Was a clay fired doll found in Nampa, Idaho during a well drilling. Early dating attempts believed the artifact to be 2 million years old due to the rock layer it was found in.[66] Later assessments found that the artifact was either only a few thousand years old[67] or a 19th-century Native American doll. Many have criticized the object as a likely hoax.[68]
- Wolfsegg Iron: Thought to be from the Tertiary epoch; actually from an early mining operation. Inaccurately described as a perfect cube.[69]
Modern-day creations, forgeries and hoaxes[edit]
- Babylonokia: A clay tablet shaped like a mobile phone and created as an artwork in 2012. Fringe scientists and alternative archaeology proponents subsequently misrepresented a photograph of the artwork as showing an 800-year-old archaeological find. The story was popularised in a video on the YouTube channel Paranormal Crucibleand led to the object being reported by some press sources as a mystery.[70]
- Acámbaro figures: Mid-20th-century figurines of dinosaurs, attributed by Waldemar Julsrud to an ancient society.[71]
- Calaveras Skull: A human skull found by miners in Calaveras County, California, which was purported to prove that humans, mastodons, and elephants had coexisted in prehistoric California. It was later revealed to be a hoax.[72]
- Cardiff Giant: A 19th-century hoax of a ten-foot-tall supposedly petrified man exhibited as a giant from biblical times. Quickly debunked by experts, and by the confession of the forger,[73] it was nonetheless a popular marvel of the day.[74]
- Crystal skulls: Supposedly demonstrate more advanced stone-cutting skill than was previously known from pre-Columbian Mesoamerica. Appear to have been made in the 19th century.[75]
- Gosford Glyphs: A collection of Egyptian hieroglyphs in Central Coast, Australia, that have been dismissed as a hoax by authorities and academics after their discovery in the 1970s.[76]
- Ica stones: Depict Inca dinosaur-hunters, surgery, and other modern or fanciful topics. Collected by Javier Cabrera Darquea, who claimed them to be prehistoric. Later revealed to be a forgery created by a local farmer.[77]
- Japanese Paleolithic hoax: Perpetrated by discredited amateur archaeologist Shinichi Fujimura.[78]
- Kensington Runestone: A runestone purportedly unearthed in 1898 in Kensington, Minnesota entangled in the roots of a tree. Runologists have dismissed the inscription's authenticity on linguistic evidence, while geologists disagree as to whether the stone shows weathering that would indicate a medieval date.[79]
- Los Lunas Decalogue Stone: Supposedly made by pre-Columbian Israelite visitors to the Americas. Generally believed to be a modern-day hoax.[80]
- Michigan relics: Supposedly ancient artifacts which have been alleged as proof that people of an ancient Near Eastern culture had lived in the U.S. state of Michigan; they are archaeological forgeries.[81]
- Newark Holy Stones: Hoax "artifacts" used as extremely unlikely evidence that Hebrew peoples lived in the Precolumbian Americas.[82]
- Piltdown Man: Supposedly skull parts from a "missing link" hominid, but exposed as an elaborate hoax 41 years after its "discovery".[83]
- Tucson artifacts: Thirty-one lead objects that Charles E. Manier and his family found in 1924 near Picture Rocks, Arizona, which were initially thought by some to be created by early Mediterranean civilizations that had crossed the Atlantic in the first century, but were later determined to be a hoax.[84]
See also[edit]
Authors and works[edit]
- Charles Fort, researcher of anomalous phenomena
- Chariots of the Gods?, 1968 book by Erich Von Daniken
- Fortean Times
- Peter Kolosimo
- Fingerprints of the Gods, 1995 book by Graham Hancock
- Vadim Chernobrov, researcher of anomalous phenomena, writer
- Michael Cremo, author of several books including Forbidden Archeology (1993)
- Charles Berlitz, linguist and writer of anomalous phenomena
Circulatory system
Circulatory system | |
---|---|
Identifiers | |
MeSH | D002319 |
TA98 | A12.0.00.000 |
TA2 | 3891 |
FMA | 7161 |
Anatomical terminology |
The blood circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate.[1][2] It includes the cardiovascular system, or vascular system, that consists of the heart and blood vessels (from Greek kardia meaning heart, and from Latin vascula meaning vessels). The circulatory system has two divisions, a systemic circulation or circuit, and a pulmonary circulation or circuit.[3] Some sources use the terms cardiovascular system and vascular system interchangeably with the circulatory system.[4]
The network of blood vessels are the great vessels of the heart including large elastic arteries, and large veins; other arteries, smaller arterioles, capillaries that join with venules (small veins), and other veins. The circulatory system is closed in vertebrates, which means that the blood never leaves the network of blood vessels. Some invertebrates such as arthropods have an open circulatory system. Diploblasts such as sponges, and comb jellies lack a circulatory system.
Blood is a fluid consisting of plasma, red blood cells, white blood cells, and platelets; it is circulated around the body carrying oxygen and nutrients to the tissues and collecting and disposing of waste materials. Circulated nutrients include proteins and minerals and other components include hemoglobin, hormones, and gases such as oxygen and carbon dioxide. These substances provide nourishment, help the immune systemto fight diseases, and help maintain homeostasis by stabilizing temperature and natural pH.
In vertebrates, the lymphatic system is complementary to the circulatory system. The lymphatic system carries excess plasma (filtered from the circulatory system capillaries as interstitial fluid between cells) away from the body tissues via accessory routes that return excess fluid back to blood circulation as lymph.[5] The lymphatic system is a subsystem that is essential for the functioning of the blood circulatory system; without it the blood would become depleted of fluid.
The lymphatic system also works with the immune system.[6] The circulation of lymph takes much longer than that of blood[7] and, unlike the closed (blood) circulatory system, the lymphatic system is an open system. Some sources describe it as a secondary circulatory system.
The circulatory system can be affected by many cardiovascular diseases. Cardiologists are medical professionals which specialise in the heart, and cardiothoracic surgeons specialise in operating on the heart and its surrounding areas. Vascular surgeons focus on disorders of the blood vessels, and lymphatic vessels.
Structure
The circulatory system includes the heart, blood vessels, and blood.[2] The cardiovascular system in all vertebrates, consists of the heart and blood vessels. The circulatory system is further divided into two major circuits – a pulmonary circulation, and a systemic circulation.[8][1][3] The pulmonary circulation is a circuit loop from the right heart taking deoxygenated blood to the lungs where it is oxygenated and returned to the left heart. The systemic circulation is a circuit loop that delivers oxygenated blood from the left heart to the rest of the body, and returns deoxygenated blood back to the right heart via large veinsknown as the venae cavae. The systemic circulation can also be defined as two parts – a macrocirculation and a microcirculation. An average adult contains five to six quarts (roughly 4.7 to 5.7 liters) of blood, accounting for approximately 7% of their total body weight.[9] Blood consists of plasma, red blood cells, white blood cells, and platelets. The digestive system also works with the circulatory system to provide the nutrients the system needs to keep the heartpumping.[10]
Further circulatory routes are associated, such as the coronary circulation to the heart itself, the cerebral circulation to the brain, renal circulation to the kidneys, and bronchial circulation to the bronchi in the lungs.
The human circulatory system is closed, meaning that the blood is contained within the vascular network.[11] Nutrients travel through tiny blood vessels of the microcirculation to reach organs.[11] The lymphatic system is an essential subsystem of the circulatory system consisting of a network of lymphatic vessels, lymph nodes, organs, tissues and circulating lymph. This subsystem is an open system.[12] A major function is to carry the lymph, draining and returning interstitial fluid into the lymphatic ducts back to the heart for return to the circulatory system. Another major function is working together with the immune system to provide defense against pathogens.[13]
Heart
The heart pumps blood to all parts of the body providing nutrients and oxygen to every cell, and removing waste products. The left heart pumps oxygenated blood returned from the lungs to the rest of the body in the systemic circulation. The right heart pumps deoxygenated blood to the lungs in the pulmonary circulation. In the human heart there is one atrium and one ventricle for each circulation, and with both a systemic and a pulmonary circulation there are four chambers in total: left atrium, left ventricle, right atrium and right ventricle. The right atrium is the upper chamber of the right side of the heart. The blood that is returned to the right atrium is deoxygenated (poor in oxygen) and passed into the right ventricle to be pumped through the pulmonary artery to the lungs for re-oxygenation and removal of carbon dioxide. The left atrium receives newly oxygenated blood from the lungs as well as the pulmonary vein which is passed into the strong left ventricle to be pumped through the aorta to the different organs of the body.
Pulmonary circulation
The pulmonary circulation is the part of the circulatory system in which oxygen-depleted blood is pumped away from the heart, via the pulmonary artery, to the lungs and returned, oxygenated, to the heart via the pulmonary vein.
Oxygen-deprived blood from the superior and inferior vena cava enters the right atrium of the heart and flows through the tricuspid valve (right atrioventricular valve) into the right ventricle, from which it is then pumped through the pulmonary semilunar valve into the pulmonary artery to the lungs. Gas exchange occurs in the lungs, whereby CO2 is released from the blood, and oxygen is absorbed. The pulmonary vein returns the now oxygen-rich blood to the left atrium.[10]
A separate circuit from the systemic circulation, the bronchial circulation supplies blood to the tissue of the larger airways of the lung.
Systemic circulation
The systemic circulation is a circuit loop that delivers oxygenated blood from the left heart to the rest of the body through the aorta. Deoxygenated blood is returned in the systemic circulation to the right heart via two large veins, the inferior vena cava and superior vena cava, where it is pumped from the right atrium into the pulmonary circulation for oxygenation. The systemic circulation can also be defined as having two parts – a macrocirculation and a microcirculation.[10]
Blood vessels
The blood vessels of the circulatory system are the arteries, veins, and capillaries. The large arteries and veins that take blood to, and away from the heart are known as the great vessels.[14]
Arteries
Oxygenated blood enters the systemic circulation when leaving the left ventricle, via the aortic semilunar valve.[15]The first part of the systemic circulation is the aorta, a massive and thick-walled artery. The aorta arches and gives branches supplying the upper part of the body after passing through the aortic opening of the diaphragm at the level of thoracic ten vertebra, it enters the abdomen.[16] Later, it descends down and supplies branches to abdomen, pelvis, perineum and the lower limbs.[17]
The walls of the aorta are elastic. This elasticity helps to maintain the blood pressure throughout the body.[18]When the aorta receives almost five litres of blood from the heart, it recoils and is responsible for pulsating blood pressure. As the aorta branches into smaller arteries, their elasticity goes on decreasing and their compliance goes on increasing.[18]
Capillaries
Arteries branch into small passages called arterioles and then into the capillaries.[19] The capillaries merge to bring blood into the venous system.[20]
Veins
Capillaries merge into venules, which merge into veins.[21] The venous system feeds into the two major veins: the superior vena cava – which mainly drains tissues above the heart – and the inferior vena cava – which mainly drains tissues below the heart. These two large veins empty into the right atrium of the heart.[22]
Portal veins
The general rule is that arteries from the heart branch out into capillaries, which collect into veins leading back to the heart. Portal veins are a slight exception to this. In humans, the only significant example is the hepatic portal vein which combines from capillaries around the gastrointestinal tract where the blood absorbs the various products of digestion; rather than leading directly back to the heart, the hepatic portal vein branches into a second capillary system in the liver.
Coronary circulation
The heart itself is supplied with oxygen and nutrients through a small "loop" of the systemic circulation and derives very little from the blood contained within the four chambers. The coronary circulation system provides a blood supply to the heart muscle itself. The coronary circulation begins near the origin of the aorta by two coronary arteries: the right coronary artery and the left coronary artery. After nourishing the heart muscle, blood returns through the coronary veins into the coronary sinus and from this one into the right atrium. Backflow of blood through its opening during atrial systole is prevented by the Thebesian valve. The smallest cardiac veins drain directly into the heart chambers.[10]
Cerebral circulation
The brain has a dual blood supply, an anterior and a posterior circulation from arteries at its front and back. The anterior circulation arises from the internal carotid arteries to supply the front of the brain. The posterior circulation arises from the vertebral arteries, to supply the back of the brain and brainstem. The circulation from the front and the back join (anastomise) at the circle of Willis. The neurovascular unit, composed of various cells and vasculature channels within the brain, regulates the flow of blood to activated neurons in order to satisfy their high energy demands.[23]
Renal circulation
The renal circulation is the blood supply to the kidneys, contains many specialized blood vessels and receives around 20% of the cardiac output. It branches from the abdominal aorta and returns blood to the ascending inferior vena cava.
Development
The development of the circulatory system starts with vasculogenesis in the embryo. The human arterial and venous systems develop from different areas in the embryo. The arterial system develops mainly from the aortic arches, six pairs of arches that develop on the upper part of the embryo. The venous system arises from three bilateral veins during weeks 4 – 8 of embryogenesis. Fetal circulation begins within the 8th week of development. Fetal circulation does not include the lungs, which are bypassed via the truncus arteriosus. Before birth the fetus obtains oxygen (and nutrients) from the mother through the placenta and the umbilical cord.[24]
Arteries
The human arterial system originates from the aortic arches and from the dorsal aortae starting from week 4 of embryonic life. The first and second aortic arches regress and form only the maxillary arteries and stapedial arteries respectively. The arterial system itself arises from aortic arches 3, 4 and 6 (aortic arch 5 completely regresses).
The dorsal aortae, present on the dorsal side of the embryo, are initially present on both sides of the embryo. They later fuse to form the basis for the aorta itself. Approximately thirty smaller arteries branch from this at the back and sides. These branches form the intercostal arteries, arteries of the arms and legs, lumbar arteries and the lateral sacral arteries. Branches to the sides of the aorta will form the definitive renal, suprarenal and gonadal arteries. Finally, branches at the front of the aorta consist of the vitelline arteries and umbilical arteries. The vitelline arteries form the celiac, superior and inferior mesenteric arteries of the gastrointestinal tract. After birth, the umbilical arteries will form the internal iliac arteries.
Veins
The human venous system develops mainly from the vitelline veins, the umbilical veins and the cardinal veins, all of which empty into the sinus venosus.
Function
About 98.5% of the oxygen in a sample of arterial blood in a healthy human, breathing air at sea-level pressure, is chemically combined with hemoglobinmolecules. About 1.5% is physically dissolved in the other blood liquids and not connected to hemoglobin. The hemoglobin molecule is the primary transporter of oxygen in vertebrates.
Clinical significance
Many diseases affect the circulatory system. These include a number of cardiovascular diseases, affecting the heart and blood vessels; hematologic diseases that affect the blood, such as anemia, and lymphatic diseases affecting the lymphatic system. Cardiologists are medical professionals which specialise in the heart, and cardiothoracic surgeons specialise in operating on the heart and its surrounding areas. Vascular surgeons focus on the blood vessels.
Cardiovascular disease
Diseases affecting the cardiovascular system are called cardiovascular disease.
Many of these diseases are called "lifestyle diseases" because they develop over time and are related to a person's exercise habits, diet, whether they smoke, and other lifestyle choices a person makes. Atherosclerosis is the precursor to many of these diseases. It is where small atheromatous plaquesbuild up in the walls of medium and large arteries. This may eventually grow or rupture to occlude the arteries. It is also a risk factor for acute coronary syndromes, which are diseases that are characterised by a sudden deficit of oxygenated blood to the heart tissue. Atherosclerosis is also associated with problems such as aneurysm formation or splitting ("dissection") of arteries.
Another major cardiovascular disease involves the creation of a clot, called a "thrombus". These can originate in veins or arteries. Deep venous thrombosis, which mostly occurs in the legs, is one cause of clots in the veins of the legs, particularly when a person has been stationary for a long time. These clots may embolise, meaning travel to another location in the body. The results of this may include pulmonary embolus, transient ischaemic attacks, or stroke.
Cardiovascular diseases may also be congenital in nature, such as heart defects or persistent fetal circulation, where the circulatory changes that are supposed to happen after birth do not. Not all congenital changes to the circulatory system are associated with diseases, a large number are anatomical variations.
Investigations
The function and health of the circulatory system and its parts are measured in a variety of manual and automated ways. These include simple methods such as those that are part of the cardiovascular examination, including the taking of a person's pulse as an indicator of a person's heart rate, the taking of blood pressure through a sphygmomanometer or the use of a stethoscope to listen to the heart for murmurs which may indicate problems with the heart's valves. An electrocardiogram can also be used to evaluate the way in which electricity is conducted through the heart.
Other more invasive means can also be used. A cannula or catheter inserted into an artery may be used to measure pulse pressure or pulmonary wedge pressures. Angiography, which involves injecting a dye into an artery to visualise an arterial tree, can be used in the heart (coronary angiography) or brain. At the same time as the arteries are visualised, blockages or narrowings may be fixed through the insertion of stents, and active bleeds may be managed by the insertion of coils. An MRI may be used to image arteries, called an MRI angiogram. For evaluation of the blood supply to the lungs a CT pulmonary angiogram may be used. Vascular ultrasonographymay be used to investigate vascular diseases affecting the venous system and the arterial system including the diagnosis of stenosis, thrombosis or venous insufficiency. An intravascular ultrasound using a catheter is also an option.
Surgery
There are a number of surgical procedures performed on the circulatory system:
- Coronary artery bypass surgery
- Coronary stent used in angioplasty
- Vascular surgery
- Vein stripping
- Cosmetic procedures
Cardiovascular procedures are more likely to be performed in an inpatient setting than in an ambulatory care setting; in the United States, only 28% of cardiovascular surgeries were performed in the ambulatory care setting.[25]
Other animals
While humans, as well as other vertebrates, have a closed blood circulatory system (meaning that the blood never leaves the network of arteries, veins and capillaries), some invertebrate groups have an open circulatory system containing a heart but limited blood vessels. The most primitive, diploblastic animal phyla lack circulatory systems.
An additional transport system, the lymphatic system, which is only found in animals with a closed blood circulation, is an open system providing an accessory route for excess interstitial fluid to be returned to the blood.[5]
The blood vascular system first appeared probably in an ancestor of the triploblasts over 600 million years ago, overcoming the time-distance constraints of diffusion, while endothelium evolved in an ancestral vertebrate some 540–510 million years ago.[26]
Open circulatory system
In arthropods, the open circulatory system is a system in which a fluid in a cavity called the hemocoel bathes the organs directly with oxygen and nutrients, with there being no distinction between blood and interstitial fluid; this combined fluid is called hemolymph or haemolymph.[27] Muscular movements by the animal during locomotion can facilitate hemolymph movement, but diverting flow from one area to another is limited. When the heart relaxes, blood is drawn back toward the heart through open-ended pores (ostia).
Hemolymph fills all of the interior hemocoel of the body and surrounds all cells. Hemolymph is composed of water, inorganic salts (mostly sodium, chloride, potassium, magnesium, and calcium), and organic compounds (mostly carbohydrates, proteins, and lipids). The primary oxygen transporter molecule is hemocyanin.
There are free-floating cells, the hemocytes, within the hemolymph. They play a role in the arthropod immune system.
Closed circulatory system
The circulatory systems of all vertebrates, as well as of annelids (for example, earthworms) and cephalopods(squids, octopuses and relatives) always keep their circulating blood enclosed within heart chambers or blood vessels and are classified as closed, just as in humans. Still, the systems of fish, amphibians, reptiles, and birdsshow various stages of the evolution of the circulatory system.[28] Closed systems permit blood to be directed to the organs that require it.
In fish, the system has only one circuit, with the blood being pumped through the capillaries of the gills and on to the capillaries of the body tissues. This is known as single cycle circulation. The heart of fish is, therefore, only a single pump (consisting of two chambers).
In amphibians and most reptiles, a double circulatory system is used, but the heart is not always completely separated into two pumps. Amphibians have a three-chambered heart.
In reptiles, the ventricular septum of the heart is incomplete and the pulmonary artery is equipped with a sphincter muscle. This allows a second possible route of blood flow. Instead of blood flowing through the pulmonary artery to the lungs, the sphincter may be contracted to divert this blood flow through the incomplete ventricular septum into the left ventricle and out through the aorta. This means the blood flows from the capillaries to the heart and back to the capillaries instead of to the lungs. This process is useful to ectothermic (cold-blooded) animals in the regulation of their body temperature.
Mammals, birds and crocodilians show complete separation of the heart into two pumps, for a total of four heart chambers; it is thought that the four-chambered heart of birds and crocodilians evolved independently from that of mammals.[29] Double circulatory systems permit blood to be repressurized after returning from the lungs, speeding up delivery of oxygen to tissues.
No circulatory system
Circulatory systems are absent in some animals, including flatworms. Their body cavity has no lining or enclosed fluid. Instead, a muscular pharynx leads to an extensively branched digestive system that facilitates direct diffusion of nutrients to all cells. The flatworm's dorso-ventrally flattened body shape also restricts the distance of any cell from the digestive system or the exterior of the organism. Oxygen can diffuse from the surrounding water into the cells, and carbon dioxide can diffuse out. Consequently, every cell is able to obtain nutrients, water and oxygen without the need of a transport system.
Some animals, such as jellyfish, have more extensive branching from their gastrovascular cavity (which functions as both a place of digestion and a form of circulation), this branching allows for bodily fluids to reach the outer layers, since the digestion begins in the inner layers.
History
The earliest known writings on the circulatory system are found in the Ebers Papyrus (16th century BCE), an ancient Egyptian medical papyrus containing over 700 prescriptions and remedies, both physical and spiritual. In the papyrus, it acknowledges the connection of the heart to the arteries. The Egyptians thought air came in through the mouth and into the lungs and heart. From the heart, the air travelled to every member through the arteries. Although this concept of the circulatory system is only partially correct, it represents one of the earliest accounts of scientific thought.
In the 6th century BCE, the knowledge of circulation of vital fluids through the body was known to the Ayurvedicphysician Sushruta in ancient India.[30] He also seems to have possessed knowledge of the arteries, described as 'channels' by Dwivedi & Dwivedi (2007).[30] The valves of the heart were discovered by a physician of the Hippocratean school around the 4th century BCE. However, their function was not properly understood then. Because blood pools in the veins after death, arteries look empty. Ancient anatomists assumed they were filled with air and that they were for the transport of air.
The Greek physician, Herophilus, distinguished veins from arteries but thought that the pulse was a property of arteries themselves. Greek anatomist Erasistratus observed that arteries that were cut during life bleed. He ascribed the fact to the phenomenon that air escaping from an artery is replaced with blood that enters between veins and arteries by very small vessels. Thus he apparently postulated capillaries but with reversed flow of blood.[citation needed]
In 2nd-century AD Rome, the Greek physician Galen knew that blood vessels carried blood and identified venous (dark red) and arterial (brighter and thinner) blood, each with distinct and separate functions. Growth and energy were derived from venous blood created in the liver from chyle, while arterial blood gave vitality by containing pneuma (air) and originated in the heart. Blood flowed from both creating organs to all parts of the body where it was consumed and there was no return of blood to the heart or liver. The heart did not pump blood around, the heart's motion sucked blood in during diastole and the blood moved by the pulsation of the arteries themselves.
Galen believed that the arterial blood was created by venous blood passing from the left ventricle to the right by passing through 'pores' in the interventricular septum, air passed from the lungs via the pulmonary artery to the left side of the heart. As the arterial blood was created 'sooty' vapors were created and passed to the lungs also via the pulmonary artery to be exhaled.
In 1025, The Canon of Medicine by the Persian physician, Avicenna, "erroneously accepted the Greek notion regarding the existence of a hole in the ventricular septum by which the blood traveled between the ventricles." Despite this, Avicenna "correctly wrote on the cardiac cycles and valvular function", and "had a vision of blood circulation" in his Treatise on Pulse.[31][verification needed] While also refining Galen's erroneous theory of the pulse, Avicenna provided the first correct explanation of pulsation: "Every beat of the pulse comprises two movements and two pauses. Thus, expansion : pause : contraction : pause. [...] The pulse is a movement in the heart and arteries ... which takes the form of alternate expansion and contraction."[32]
In 1242, the Arabian physician, Ibn al-Nafis described the process of pulmonary circulation in greater, more accurate detail than his predecessors, though he believed, as they did, in the notion of vital spirit (pneuma), which he believed was formed in the left ventricle. Ibn al-Nafis stated in his Commentary on Anatomy in Avicenna's Canon:
In addition, Ibn al-Nafis had an insight into what would become a larger theory of the capillary circulation. He stated that "there must be small communications or pores (manafidh in Arabic) between the pulmonary artery and vein," a prediction that preceded the discovery of the capillary system by more than 400 years.[33] Ibn al-Nafis' theory, however, was confined to blood transit in the lungs and did not extend to the entire body.
Michael Servetus was the first European to describe the function of pulmonary circulation, although his achievement was not widely recognized at the time, for a few reasons. He firstly described it in the "Manuscript of Paris"[34][35] (near 1546), but this work was never published. And later he published this description, but in a theological treatise, Christianismi Restitutio, not in a book on medicine. Only three copies of the book survived but these remained hidden for decades, the rest were burned shortly after its publication in 1553 because of persecution of Servetus by religious authorities.
A better known discovery of pulmonary circulation was by Vesalius's successor at Padua, Realdo Colombo, in 1559.
Finally, the English physician William Harvey, a pupil of Hieronymus Fabricius (who had earlier described the valves of the veins without recognizing their function), performed a sequence of experiments and published his Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus in 1628, which "demonstrated that there had to be a direct connection between the venous and arterial systems throughout the body, and not just the lungs. Most importantly, he argued that the beat of the heart produced a continuous circulation of blood through minute connections at the extremities of the body. This is a conceptual leap that was quite different from Ibn al-Nafis' refinement of the anatomy and bloodflow in the heart and lungs."[36] This work, with its essentially correct exposition, slowly convinced the medical world. However, Harvey was not able to identify the capillary system connecting arteries and veins; these were later discovered by Marcello Malpighi in 1661.
In 1956, André Frédéric Cournand, Werner Forssmann and Dickinson W. Richards were awarded the Nobel Prizein Medicine "for their discoveries concerning heart catheterization and pathological changes in the circulatory system."[37] In his Nobel lecture, Forssmann credits Harvey as birthing cardiology with the publication of his book in 1628.[38]
In the 1970s, Diana McSherry developed computer-based systems to create images of the circulatory system and heart without the need for surgery.[39]
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"TOOTH" in the KJV Bible
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- Exodus 21:27chapter context similar meaning copy save
- And if he smite out his manservant's tooth, or his maidservant's tooth; he shall let him go free for his tooth's sake.
- Matthew 5:38chapter context similar meaning copy save
- Ye have heard that it hath been said, An eye for an eye, and a tooth for a tooth:
- Leviticus 24:20chapter context similar meaning copy save
- Breach for breach, eye for eye, tooth for tooth: as he hath caused a blemish in a man, so shall it be done to him again.
- Deuteronomy 19:21chapter context similar meaning copy save
- And thine eye shall not pity; but life shall go for life, eye for eye, tooth for tooth, hand for hand, foot for foot.
- Proverbs 25:19chapter context similar meaning copy save
- Confidence in an unfaithful man in time of trouble is like a broken tooth, and a foot out of joint.
- Exodus 21:24chapter context similar meaning copy save
- Eye for eye, tooth for tooth, hand for hand, foot for foot,
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